Molecular mechanism in the development and progression of prostate cancer
10.3724/SP.J.1008.2014.01310
- Author:
Ji LIN
1
Author Information
1. Department of Epidemiology, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Chronic prostatitis;
Molecular mechanisms;
Mutation;
Prostatic neoplasms
- From:
Academic Journal of Second Military Medical University
2014;35(12):1310-1314
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of prostate cancer has been greatly increased in China and it has ranked the 5th of the malignant tumors in Chinese males. Continuous environment stimulation causes chronic prostatic inflammation, and infiltration of inflammatory cytokines such as INF-γ, TNF-α, and TGF-β can cause damage and repair of prostatic tissues, leading to proliferative inflammatory atrophy (PIA). Then a small subset of cells will develop somatic genome alterations, including overexpression of MYC and the loss of NKX3. 1 and PTEN, which can promote PIA into prostatic intraepithelial neoplasia. Androgen receptor mutation and ERG-TMPRSS2 fusion will drive progression of prostatic cancer.
