Long noncoding RNAs and lung cancer
10.3724/SP.J.1008.2014.01115
- Author:
Jie CHEN
1
Author Information
1. Department of Respiratory Medicine, Changhai Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Gene expression regulation;
Long noncoding RNAs;
Lung neoplasms
- From:
Academic Journal of Second Military Medical University
2014;35(10):1115-1120
- CountryChina
- Language:Chinese
-
Abstract:
Long noncoding RNAs (lncRNAs), contraining more than 200 nucleotides, are RNA transcripts without protein-coding capacity. It has been reported that lncRNAs regulate gene expression at the epigenetic, transcriptional and post-transcriptional levels, and are deeply involved in various biological processes. Many diseases are found related to lncRNAs and they have become a focus of studies. According to recent evidences, a number of lncRNAs are changed in lung cancer, and they play a significant part in the development, progression and prognosis of lung cancer. This review focuses on the definition and functional mechanism of lncRNAs and their relation with lung cancer.
