Antioxidant defense of peroxiredoxin 6 in lung: Recent progress
10.3724/SP.J.1008.2014.01121
- Author:
Hao-Jun LIANG
1
Author Information
1. Department of Human Anatomy, College of Basic Medical Sciences, Jilin University
- Publication Type:Journal Article
- Keywords:
Apoptosis;
Lung diseases;
Oxidative stress;
Peroxiredoxin VI
- From:
Academic Journal of Second Military Medical University
2014;35(10):1121-1125
- CountryChina
- Language:Chinese
-
Abstract:
Alveolar epithelial apoptosis and injury induced by oxidative stress in pulmonary diseases have drawn great attention from researchers. Peroxiredoxin 6 (Prdx6), endowed with the activities of both glutathione (GSH) peroxidase and phospholipase A2(PLA2), can effectively fight against oxidative stress and alleviate oxidative stress-induced lung injury, and therefore plays an important role in pulmonary diseases. This review focuses on the structure, function, distribution and expression regulation of Prdx6, and summarizes the role of Prdx6 in pulmonary antioxidant defense and its regulatory mechanism based on experimental studies.
