Effects of target-controlled infusion of propofol or sevoflurane combined with remifentanil on cerebral oxygen metabolism: A comparison study
10.3724/SP.J.1008.2014.00804
- Author:
Jun PU
1
Author Information
1. Department of Anesthesiology, Changzheng Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Brain neoplasms;
Cerebral oxygen metabolism;
Neurosurgical procedures;
Propofol;
Remifentanil;
Sevoflurane
- From:
Academic Journal of Second Military Medical University
2014;35(7):804-807
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the effects of target-controlled infusion (TCI) between propofol/remifentanil and sevoflurane/remifentanil during anesthesia on cerebral oxygen metabolism in patients undergoing brain tumor surgery, so as to provide references for clinical practice. Methods: A double-blind randomized, controlled trial was conducted with sixty participants, which were equally assigned to two groups. Patients in the PR Group were induced by TCI of propofol/remifentanil combination and those in the SR Group were anesthetized with sevoflurane/remifentanil combination. Blood samples were collected at different time points to measure jugular bulb venous oxygen saturation (SjvO2) and generate arteriovenous oxygen content difference (Da-jvO2). The hemodynamic parameters and duration of surgery or anesthesia of each participant were also monitored and recorded. Results: No significant difference was found regarding to the hemodynamic parameters or duration of surgery/anesthesia between the two groups. SjvO2 was found significantly higher and Da-jvO2 was significantly lower in the SR group than those in the PR group(P<0.01). Conclusion: Combined anesthesia with propofol/remifentanil vs sevoflurane/remifentanil are both safe for patients undergoing cerebral tumor operation; and sevoflurane/remifentanil seems to provide better oxygen supply and has more rapid post-operation recovery; however, sevoflurane/remifentanil can improve cerebral oxygenation.
