Molecular targeted therapy of gastric cancer; recent progress
10.3724/SP.J.1008.2014.00305
- Author:
Zai-Biao WANG
1
Author Information
1. Department of General Surgery, Changhai Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Cyclooxygenase-2;
Epidermal growth factor receptor;
Molecular targeted therapy;
Stomach neoplasms;
Vascular endothelial growth factor receptor;
Vascular endothelial growth factors
- From:
Academic Journal of Second Military Medical University
2014;35(3):305-311
- CountryChina
- Language:Chinese
-
Abstract:
Despite chemotherapy regimens foradvanced gastric cancer keep emerging, the patients stillhave poor prognosis. Molecular targeted therapy is another important direction for the treatment of advanced gastric cancer. Various drugs for molecular targeted therapy have been developed targeting epidermal growth factor receptor (EGFR), human epidermal growth factor receptor-2 (HER-2), vascular endothelial growth factor (VEGF) and its receptor (VEGFR), and cyclooxygenase-2 (COX-2); a number of II /W clinical trial have been completed or being conducted. The aim of this review is to summarize the recent progress on molecular targeted therapy for gastric cancer.
