Relationship between LDL-C/HDL-C and severity of coronary artery disease
10.3724/SP.J.1008.2014.00270
- Author:
Ming-Chun LI
1
Author Information
1. Department of Hypertension, Ruijin Hospital (North), Shanghai Jiaotong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Coronary disease;
HDL cholesterol;
LDL cholesterol;
Lipids
- From:
Academic Journal of Second Military Medical University
2014;35(3):270-273
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between blood lipids and the severity of coronary artery disease. Methods A total of 4 751 patients with chest pain were divided into two groups according to the results of coronary angiography: coronary artery disease group (n = 3 402 stenosis in one main branch stenosis ≥ 50%) and control group (stenosis<50%, n = 1 349). According tothe number of coronary artery stenosis, the coronary artery disease group was divided into three subgroups (group 1: 1branch stenosis; group 2: 2 branch stenosis; and group 3: 3 or more than 3 branch stenosis). The serum total cholesterol (TC), triglycefides (TG),high density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were determined and LDL-C/HDL-C was calculated. The relationship between lipids and the severity of coronary artery stenosis was analyzed by Spearman correlation analysis, and the risk factors of coronary artery disease were analyzed by multiple-stepwise logistic regression analysis. Results The levels of TG, TC, LDL-C and the ratio of LDL-C/HDL-C in the coronary artery disease group were significantly lower than those in the control group (P<0. 01). LDL- C/HDL-C ratio increased with the increase of diseased branches in the disease group (P<0. 001), and the number of diseased branches was positively correlated with the ratio of LDL-C/HDL-C (R = 0. 25, P<0. 01). Logistic multiple regression analysis showed that high LDL-C/HDL-C level was an independent risk factor for coronary heart disease. Conclusion LDL-C/HDL-C ratio is an independent risk factor for coronary heart disease and it is positively correlated with the severity of coronary artery lesions.
