Nano-silver active carbon fiber dressings improving bedsore wound healing in rats
10.3724/SP.J.1008.2015.01051
- Author:
Ying WANG
1
Author Information
1. Department of Burns and Plastic Surgery, No. 85 Hospital of PLA
- Publication Type:Journal Article
- Keywords:
Activated carbon;
Inflammatory factors;
Nano silver;
Pressure ulcer;
Vascular endothelial growth factors
- From:
Academic Journal of Second Military Medical University
2015;36(10):1051-1055
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of nano-silver active carbon fiber dressings on wound healing in bedsore wound animal models. Methods Adult SD rats were used and bedsore wound models were made on their back; the animals were then randomly divided into 5 groups (n=10) according to different materials of the wound dressing and treatment. Groups were treated with nano-silver active carbon dressings, nano-silver dressings, active carbon dressings, Vaseline chlorhexidine dressings, or blank control. The wound healing situation, contents of angiogenic factors and inflammatory factors in wound tissues were compared among the 5 groups. Results Wound healing time and the healing rates were different among the 5 groups, with the healing time of rats in nano-silver active carbon dressing group being significantly shorter than those in the other 4 groups (P<0.05). On the 3rd, 7th, 14th and 21st days after bedsore wound modeling, the healing rates of nano-silver active carbon dressing group were significantly higher than those of the other 4 groups (P<0.05). The levels of angiogenesis factors and inflammatory factors were different in wound tissues of five groups, with the contents of VEGFA, VEGFB and VEGFC mRNA in nano-silver active carbon dressing group being significantly higher and the contents of TNF-α, IL-2 and IL-8 mRNA being significantly lower than those of the other 4 groups (P<0.05). Conclusion The prepared nano-silver active carbon fiber dressing can help to improve pressure ulcer wound healing, relieve wound inflammation, and promote angiogenesis in the wound; it may serve as an ideal material for treating bedsore wound.
