Effect of topical glucocorticoid on skin barrier function of patients with senile xerosis
10.16781/j.0258-879x.2016.11.1437
- Author:
Jing ZHOU
1
Author Information
1. Department of Dermatology, Shanghai Dermatology Hospital
- Publication Type:Journal Article
- Keywords:
Glucocorticoids;
Senile xerosis;
Skin barrier
- From:
Academic Journal of Second Military Medical University
2016;37(11):1437-1439
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of topical glucocorticoid on skin barrier function of patients with senile xerosis. Methods A total of 32 patients were treated with 0. 1% topical hydrocortisone cream on one side of the forearms (topical hydrocortisone group), once a xggiday for 8 weeks, and the other forearms were taken as control (control group). Skin barrier function was evaluated at 0, 2, 4 and 8 weeks after experiment using Corneometer and Tewameter. Results The water content of stratum corneum in the topical hydrocortisone group peaked at 2 weeks, while the transepidemal water loss (TEWL) value was the lowest. Compared with the control group, topical hydrocortisone significantly increased the water content of the stratum corneum (P<0. 01) and decreased the TEWL value of stratum corneum (P<0. 01) after an 8-week treatment. Conclusion The application of topical glucocorticoid in patients with senile xerosis results in no impairment of skin barrier function after an 8-week treatment, and it can temporarily improve the skin barrier function after 2-week treatment.
