Influence of microRNAs on cordiomyocyte viability in myocardial infarction and its therapeutic potential: Research progress
10.16781/j.0258-879x.2016.08.0996
- Author:
Ning WANG
1
Author Information
1. Department of Cardiovascular Surgery, Dalian Children’ Hospital, Dalian Medical University
- Publication Type:Journal Article
- Keywords:
Cardiac myocytes;
Heart failure;
MicroRNAs;
Myocardial infaction
- From:
Academic Journal of Second Military Medical University
2016;37(8):996-1001
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRs), initially discovered in eukaryotes, are endogenous small noncoding RNAs that regulate gene expression. Myocardial infarction is a common cardiovascular event resulting in cardiac remodeling and subsequent chronic heart failure. A number of miRs have been reported to regulate important pathophysiological processes of myocardial infarction. They have multiple effects on the survival and proliferation of cardiomyocytes, which is of great significance to myocardial infarction and other ischemic heart diseases. In this review we introduced the general knowledge of myocardial infarction and miRs, and described several miRs which are crucial for survival and proliferation of cardiomyocytes. We also discussed the therapeutic potential and limitations of miRs in future treatment of myocardial infarction.
