Activation and regulation of NLRP3 inflammasome: Research progress
10.16781/j.0258-879x.2016.07.0868
- Author:
Yan-Gang LIU
1
Author Information
1. Department of Health Toxicology, Faculty of Tropical Medicine and Public Health, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Activation mechanism;
Innate immunity;
Negative regulation;
NLRP3 inflammasome;
Pyroptosis
- From:
Academic Journal of Second Military Medical University
2016;37(7):868-872
- CountryChina
- Language:Chinese
-
Abstract:
Inflammasome is a vital part of innate immunity, and NLRP3 inflammasome is by far the most thoroughly studied inflammasome complexes that have been described. NLRP3activating signals include toxins secreted by pathogens, crystalline moleculesand endogenous danger signals. Activation of NLRP3 inflammasome needs two steps: priming and activating. The priming step affects NLRP3 at the transcriptional and posttranscriptional modification levels * the activating step is associated with ion flowing, mitochondria and lysosomes. In this paper we also reviewed the negative regulation of NLRP3 inflammasome at the expression, assembly and activation levels.
