Role of vascular endothelial growth factor-a in kidney development and kidney diseases
10.16781/j.0258-879g2016.07.0863
- Author:
Jie ZHOU
1
Author Information
1. Department of Nephrology, Kidney Institute of PLA, Changzheng Hospital,Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Kidney diseases;
Renal vascular system;
Vascular endothelial growth factor-A
- From:
Academic Journal of Second Military Medical University
2016;37(7):863-867
- CountryChina
- Language:Chinese
-
Abstract:
The renal vascular system is vital for maintaining the normal function of kidney, and vascular endothelial growth factor-A (vEGF-A) participates in the development of renal vascular.system and is associated withvarious kidney diseases. Studies have demonstrated that down-expression of renal vEGF-A can result in reduction of microvascular density in medulla kidney, regional hypoxia, and polycythemia, and further lead to increased haemopoietin. The overexpression of vEGF- A can cause renal fibrosis and cyst formation, promoting the progress of kidney disease. Therefore, regulation of vEGF-A expression may influence the occurrence and development of kidney diseases. This review summarized the role of vEGF-A in the renal vascular system and kidney diseases hoping to provide new therapeutic strategies for kidney diseases.
