Serum microRNA-21 expression is significantly down-regulated in patients with dilated cardiomyopathy
10.16781/j.0258-879x.2016.03.0379
- Author:
Xu GUI-FEN
1
Author Information
1. Department of Cardiology, The First Affiliated Hospital of Fujian Medical University
- Publication Type:Journal Article
- Keywords:
Diagnosis;
Dilated cardiomyopathy;
MicroRNAs;
Serum
- From:
Academic Journal of Second Military Medical University
2016;37(3):379-382
- CountryChina
- Language:Chinese
-
Abstract:
Objective To address the levels of serum miR-21/155/181a/18b in dilated cardiomyopathy (DCM) patients at a progressive heart failure stage. Methods The serum miRNAs were measured by real-time reverse-transcription PCR in 40 DCM patients and in 30 healthy controls. Pearson’s correlation coefficient was used to calculate the potential correlation between miRNAs and other indicators, such as human Nterminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hsCRP), left ventricular ejection fraction (LVEF%), and left ventricular end-diastolic diameter (LVEDD). Results Our findings revealed that serum miR-21 were significantly reduced in DCM patients compared with the healthy controls(P<0. 01). We also found that serum miR-21 was positively correlated with LVEF% and negatively correlated with LVEDD -<0. 001). Conclusion The serum level of cardiac remodeling-associated miR-21 is decreased in DCM patients at a progressive heart failure stage compared to the healthy controls, which may be also related to the disease severity.
