Research progress on role of macrophage in fracture healing
10.16781/j.0258-879x.2017.12.1556
- Author:
Xiao-Yi ZHOU
1
Author Information
1. Department of Spine Surgery, Changhai Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Fracture;
Healing;
Inflammation;
Macrophage;
Tissue engineering
- From:
Academic Journal of Second Military Medical University
2017;38(12):1556-1561
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory reaction plays an important role in hematoma formation, tissue debris removal and fibrous tissue formation during the first stage of fracture healing. M1 and M2 macrophages participate in the process of fracture healing through pro-inflammatory and anti-inflammatory effects, respectively. Tumor necrosis factor α, interleukin and other cytokines secreted by macrophages can regulate the activities of osteoblasts and osteoclasts. Bone tissue bioengineering studies found that functional tissue engineering can promote angiogenesis and fracture healing by regulating inflammatory reaction. Therefore, exploring the role of macrophages in the process of fracture healing may provide new insights for promoting fracture healing.
