Research status of src-homology 2 domain-containing protein tyrosine phosphatase 1 in liver diseases
10.16781/j.0258-879x.2017.09.1128
- Author:
Shu-juan LEI
1
Author Information
1. Department of Gastroenterology, Changzheng Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Liver diseases;
SH2 domain-containing protein tyrosine phosphatises;
Tyrosine phosphorylation
- From:
Academic Journal of Second Military Medical University
2017;38(9):1128-1133
- CountryChina
- Language:Chinese
-
Abstract:
Protein tyrosine phosphorylation is ubiquitously found in eukaryotic cells, and it is a fundamental regulatory mechanism to be involved in the regulation of cell proliferation, apoptosis, differentiation and migration. Dysregulation of protein tyrosine phosphorylation can influence various liver diseases, such as liver inflammation, liver fibrosis and liver cancer. The src-homology 2 domain-containing protein tyrosine phosphatase 1 (SHP-1), a nonreceptor type protein tyrosine phosphatase, is a key regulator of maintaining protein tyrosine phosphorylation level in vivo. Recently, great progress in the research of SHP-1 in liver diseases has been made, and this review summed up the advances of SHP-1 in liver diseases.
