Application of next-generation sequencing in research and personalized treatment of glioma
10.16781/j.0258-879x.2017.08.1046
- Author:
Hong-Xiang WANG
1
Author Information
1. Department of Neurosurgery, Shanghai Institute of Neurosurgery, Neurosurgery Institute of PLA, Changzheng Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Brain neoplasms;
DNA sequence analysis;
Glioma;
Personalized treatment
- From:
Academic Journal of Second Military Medical University
2017;38(8):1046-1052
- CountryChina
- Language:Chinese
-
Abstract:
Glioma is a highly lethal malignancy and multiple challenges remain for it in the genomic study and clinical treatment. Next-generation sequencing (NGS) holds many advantages, and NGS can comprehensively analyze the whole genome, exome, transcriptome and epigenome to deepen the understanding of tumor genomics; and now, it has been successfully applied in the clinical study of some tumors, especially in personalized treatment for these tumors. At present, NGS has also been a hot in glioma research to clarify the pathogenesis of glioma, so as to draw up a personalized treatment method to benefit the patients.
