DNA methyldtion and asthma: Recent progress
10.16781/j.0258-879x.2017.02.0220
- Author:
Li-Ping WAN
1
Author Information
1. Department of Respiratory and Critical Care Medicine, Changhai Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Asthma;
DNA methylation;
Epigenetics;
House dust mite
- From:
Academic Journal of Second Military Medical University
2017;38(2):220-225
- CountryChina
- Language:Chinese
-
Abstract:
DNA methylation is one of the most common forms of epigenetic modification, and t is closely related to the development of bronchial asthma, but its mechanism is unclear. Without altering the sequences of genes, DNA methylation can transfer the cytosine on the 5 end of CpG dinucleotide into methyl cytosine by DNA methyltransferase. Hence, DNA methylation can regulate gene expression, leading to the development and progression of diseases. In this review, we summarized the roles of DNA methylation in bronchial asthma, including related predisposing factors and mechanisms of action.
