Presenilins in dilated cardiomyopathy: An update
10.16781/j.0258-879x.2017.01.0097
- Author:
Qing-Ning YUAN
1
Author Information
1. Department of Biophysics, College of Basic Medical Sciences, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Amyloid precusor protein;
Calcium;
Dilated cardiomyopathy;
Presenilins;
γ-secretase
- From:
Academic Journal of Second Military Medical University
2017;38(1):97-101
- CountryChina
- Language:Chinese
-
Abstract:
Presenilin (PS) is a transmembrane protein identified in familial early-onset Alzheimer disease, and it is mainly expressed in cell membranes and organelle membranes. As an important catalytic core of the γ-secretase multimeric enzyme complex, PS has been implicated in regulating various proteins. Recent researches have shown that mutations in PS are identified in the familial dilated cardiomyopathy, and the PS gene plays an important role in cardiac formation and regulation of calcium homeostasis in myocardial cells. In this review, we summarized the function of PS in heart and the mechanisms underlying the effects of PS on calcium homeostasis, such as amyloid β protein (Aβ), 1,4,5-inositol trisphosphate receptors, ryanodine receptors and PS as endoplasmic reticulum (ER) Ca2+ leak channels, hoping to provide a theoretical basis for the therapy of dilated cardiomyopathy.
