Research progress on non-coding RNA in calcific aortic valve disease
10.16781/j.0258-879x.2019.07.0705782
- VernacularTitle: RNA
- Author:
Yu ZHANG
1
Author Information
1. Department of Cardiovascular Surgery, Changhai Hospital, Naval Medical University (Second Military Medical University)
- Publication Type:Journal Article
- Keywords:
Calcific aortic valve disease;
Non-coding RNA;
Valve endothelial cells;
Valve interstitial cells
- From:
Academic Journal of Second Military Medical University
2019;40(7):782-787
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Calcific aortic valve disease is a process involving complex pathological changes such as endothelial injury, chronic inflammation, extracellular matrix remodeling, cell phenotype differentiation and apoptosis. The aortic valve is mainly composed of internal valve interstitial cells and external valve endothelial cells, and they are all involved in the pathological process of calcific aortic valve disease. Non-coding RNA participates in the pathophysiological process of cardiovascular disease mainly through post-transcriptional regulation mechanism, and may play an important role in the development and progression of calcific aortic valve disease.
