Epithelial-mesenchymal transition-related long non-coding RNA and gastric cancer
10.16781/j.0258-879x.2019.02.0209
- Author:
Jiang LI
1
Author Information
1. Department of General Surgery, Changhai Hospital, Naval Medical University (Second Military Medical University)
- Publication Type:Journal Article
- Keywords:
Epithelial-mesenchymal transition;
Long non-coding RNA;
Neoplasm invasiveness;
Neoplasm metastasis;
Stomach neoplasms
- From:
Academic Journal of Second Military Medical University
2019;40(2):209-212
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is one of the main malignancies threatening human health, and its occurrence involves multistep and multigene interactions. Epithelial-mesenchymal transition (EMT) is a biological process in which epithelial cells transform to mesenchymal phenotypic cells through specific procedures. Studies have shown that long non-coding RNAs (lncRNAs) can promote or inhibit EMT by binding to target proteins and competing microRNAs as competitive endogenous RNAs, and some specific EMT-related lncRNAs are deeply involved in the invasion and metastasis of gastric cancer. In this review, we summarized the recent mechanisms of EMT-related lncRNAs in the regulating the invasion and metastasis of gastric cancer.
