Attenuated vaccines of flavivirus genus arborvirus: An update
10.16781/j.0258-879x.2019.02.0196
- Author:
Zheng-Hao XU
1
Author Information
1. Department of Biodefense, Faculty of Naval Medicine, Naval Medical University (Second Military Medical University)
- Publication Type:Journal Article
- Keywords:
Attenuated vaccines;
Flavivirus;
Infectious clone;
Viral vaccines
- From:
Academic Journal of Second Military Medical University
2019;40(2):196-202
- CountryChina
- Language:Chinese
-
Abstract:
As a pathogen causing many infectious diseases, Flavivirus genus arborvirus has caused public health emergencies worldwide and posed a serious threat to human health. Attenuated vaccine is the most effective vaccine type against Flavivirus genus arborvirus. The attenuated vaccines against yellow fever virus and Japanese encephalitis virus obtained by consecutive cell passages play an important role in preventing viral infections. Recently, reverse genetics technique has been used to modify the flavivirus genome to obtain the attenuated phenotype, and this technique has made significant progress in the development of Flavivirus genus arbovirus vaccines. This review summarizes the history and the current status of attenuated vaccine of Flavivirus genus arborvirus.
