Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis
- Author:
Hyun Ho JO
1
;
Seong Joon CHUN
;
Jeong-Ju YOO
;
Min Hee LEE
;
Sang Gyune KIM
;
Young Seok KIM
Author Information
- Publication Type:Case Report
- From:Journal of Liver Cancer 2020;20(2):177-182
- CountryRepublic of Korea
- Language:Korean
- Abstract: JX-594 is a modified oncolytic poxvirus designed to selectively replicate in and destroy cancer cells. In a pilot study, JX-594 injection followed by sorafenib was well-tolerated in three patients and associated with objective tumor responses. In this study, we report a case in which a patient with advanced hepatocellular carcinoma and portal vein thrombosis was treated with a combination of JX-594 and sorafenib.
