Metabolic Reprogramming of Macrophages in Atherosclerosis: Is It All about Cholesterol?
10.12997/jla.2020.9.2.231
- Author:
Laurent YVAN-CHARVET
1
;
Stoyan IVANOV
Author Information
1. Institut National de la Santé et de la Recherche Médicale (Inserm) U1065, Université Côte d'Azur, Centre Méditerranéen de Médecine Moléculaire (C3M), Atip-Avenir, Fédération Hospitalo-Universitaire (FHU) Oncoage, Nice, France
- Publication Type:Review Article
- From:Journal of Lipid and Atherosclerosis
2020;9(2):231-242
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hypercholesterolemia contributes to the chronic inflammatory response during the progression of atherosclerosis, in part by favoring cholesterol loading in macrophages and other immune cells. However, macrophages encounter a substantial amount of other lipids and nutrients after ingesting atherogenic lipoprotein particles or clearing apoptotic cells, increasing their metabolic load and impacting their behavior during atherosclerosis plaque progression. This review examines whether and how fatty acids and glucose shape the cellular metabolic reprogramming of macrophages in atherosclerosis to modulate the onset phase of inflammation and the later resolution stage, in which the balance is tipped toward tissue repair.
