Effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients
- Author:
Yu Ho LEE
1
;
Yoon Soo SHIN
;
So-Young LEE
;
Yang Gyun KIM
;
Sang Ho LEE
;
Ju Young MOON
;
Kyung Hwan JEONG
;
Hyeon Seok HWANG
;
Shin Young AHN
;
Hong Joo LEE
;
Dong-Young LEE
;
Eun-Jung KO
;
Hye Jeong CHO
;
Dong Ho YANG
;
Hye Yun JEONG
Author Information
- Publication Type:Original Article
- From:Kidney Research and Clinical Practice 2020;39(1):103-111
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Online hemodiafiltration (OL-HDF) offers considerable advantages in clearance of molecules of various sizes. However, evidence of clinical effects of OL-HDF is scarce in Korea. In this study, we investigated changes in laboratory values over more than 12 months after switching to OL-HDF.
Methods:Adult patients with end-stage renal disease undergoing hemodialysis (HD) were prospectively enrolled in a K-cohort (CRIS no. KCT0003281) from 6 tertiary hospitals in South Korea. We recruited 435 patients, 339 of whom were on HD at enrollment. One hundred eighty-two patients were followed for more than 24 months. Among them, 44 were switched to OL-HDF for more than 12 months without conversion to HD. We used a paired t test to compare baseline and 24-month follow-up results.
Results:The mean age of the subjects was 61.2 ± 12.2 years, and 62.6% were male. The baseline hemoglobin level was not significantly different between HD and OL-HDF group (10.61 ± 1.15 vs. 10.46 ± 1.03 g/dL, P = 0.437). However, the baseline serum protein and albumin levels were significantly lower in the OL-HDF group (6.82 ± 0.49 vs. 6.59 ± 0.48 g/dL, P = 0.006; 3.93 ± 0.28 vs. 3.73 ± 0.29 g/dL, P < 0.001). In patients switched to OL-HDF, levels of hemoglobin and serum albumin significantly increased (10.46 ± 1.03 vs. 11.08 ± 0.82 g/dL, P = 0.001; 3.73 ± 0.29 vs.
