Long-Term Clinical Effects of Carotid Intraplaque Neovascularization in Patients with Coronary Artery Disease
- Author:
Hyemoon CHUNG
1
;
Bu Yong KIM
;
Hyun Soo KIM
;
Hyung Oh KIM
;
Jung Myung LEE
;
Jong Shin WOO
;
Jin Bae KIM
;
Woo-Shik KIM
;
Kwon Sam KIM
;
Weon KIM
Author Information
- Publication Type:Original Article
- From:Korean Journal of Radiology 2020;21(7):900-907
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:To investigate the predictive value of intraplaque neovascularization (IPN) for cardiovascular outcomes.
Materials and Methods:We evaluated 217 patients with coronary artery disease (CAD) (158 men; mean age, 68 ± 10 years) with a maximal carotid plaque thickness ≥ 1.5 mm for the presence of IPN using contrast-enhanced ultrasonography. We compared patients with (n = 116) and without (n = 101) IPN during the follow-up period and investigated the predictors of major adverse cardiovascular events (MACE), including cardiac death, myocardial infarction, coronary artery revascularization, and transient ischemic accident/stroke.
Results:During the mean follow-up period of 995 ± 610 days, the MACE rate was 6% (13/217). Patients with IPN had a higher maximal thickness than those without IPN (2.86 ± 1.01 vs. 2.61 ± 0.84 mm, p = 0.046). Common carotid artery-peak systolic velocity, left ventricular mass index (LVMI), and ventricular-vascular coupling index were significantly correlated with MACE. However, on multivariate Cox regression analysis, increased LVMI was independently related to MACE (p < 0.05). The presence of IPN could not predict MACE.
Conclusion:The presence of IPN was related to a higher plaque thickness but could not predict cardiovascular outcomes better than conventional clinical factors in patients with CAD.
