Amino Acid Transporters as Potential Therapeutic Targets in Thyroid Cancer
10.3803/EnM.2020.35.2.227
- Author:
Keisuke ENOMOTO
1
;
Muneki HOTOMI
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
- Publication Type:Review Article
- From:Endocrinology and Metabolism
2020;35(2):227-236
- CountryRepublic of Korea
- Language:English
-
Abstract:
Thyroid cancer cells have a high amino acid demand for proliferation, invasion, and metastasis. Amino acids are taken up by thyroid cancer cells, both thyroid follicular cell and thyroid parafollicular cells (commonly called “C-cells”), via amino acid transporters. Amino acid transporters up-regulate in many cancers, and their expression level associate with clinical aggressiveness and prognosis. This is the review to discuss the therapeutic potential of amino acid transporters and as molecular targets in thyroid cancer.
