Research progress of mitochondrial ferritin and age-related macular degeneration
10.3980/j.issn.1672-5123.2020.12.14
- VernacularTitle:线粒体铁蛋白和年龄相关性黄斑变性的研究进展
- Author:
Zhi-Yu Xu
1
Author Information
1. Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
- Publication Type:Review
- Keywords:
age-related macular degeneration;
mitochondrial ferritin;
oxidative stress
- From:
International Eye Science
2020;20(12):2083-2086
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration(ARMD)is a major cause of irreversible visual impairment in the elderly in developed countries. Recent studies have shown that mitochondrial ferritin(FTMT)is thought to have an antioxidant effect through iron regulation. Therefore, this paper discusses the effects of FTMT on HIF-1α, FTMT gene mutation, and FTMT protection against oxidative stress on the progression of ARMD, so as to better understand the pathogenesis of the disease and contribute to the prevention or evaluation of the disease.
- Full text:202012014.pdf
