Role of matrix metalloproteinases-2 and matrix metalloproteinases-9 in the development and progression of chronic liver diseases
DOI:10.3969/j.issn.1001-5256.2020.10.045
- VernacularTitle:基质金属蛋白酶2/9在慢性肝脏疾病发生发展中的作用
- Author:
Shangqing YANG
1
;
Dongliang YANG
;
Jia LIU
Author Information
1. Department of Infectious Diseases, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China
- Publication Type:Research Article
- Keywords:
liver diseases;
matrix metalloproteinase 2;
matrix metalloproteinase 9;
immunity
- From:
Journal of Clinical Hepatology
2020;36(10):2364-2369
- CountryChina
- Language:Chinese
-
Abstract:
The degradation and remodelling of extracellular matrix are important pathophysiological phenomena during the progression of various chronic liver diseases. With the expanded research on matrix metalloproteinases (MMPs) in recent years, it has been found that MMPs can affect the degradation and remodelling of extracellular matrix, participate in the regulation of inflammation and immune responses through various mechanisms, and thus participate in the progression of liver diseases. This article reviews the basic characteristics of matrix metalloproteinase-2 and matrix metalloproteinase-9, their regulatory mechanisms, and their role in the development and progression of chronic liver diseases, so as to provide a basis for exploring new therapeutic strategies for chronic liver diseases.
