Advances in drug-drug complexes based on the crystal engineering design
10.16438/j.0513-4870.2020-0603
- VernacularTitle:基于晶体工程设计的药物-药物复合物研究进展
- Author:
Bo PENG
1
;
Jian-rong WANG
1
Author Information
1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
cocrystal;
salt;
active pharmaceutical ingredient;
physicochemical property;
pharmacology;
pipeline
- From:
Acta Pharmaceutica Sinica
2020;55(10):2358-2367
- CountryChina
- Language:Chinese
-
Abstract:
Drug-drug complexes play important roles in improving the physicochemical properties of drugs including the solubility, dissolution rate and stability of the active pharmaceutical ingredients (APIs). In this paper, the design, synthesis, characterization, changes in physicochemical and pharmacologic properties, structural polymorphisms and the research and development pipelines of a variety of drug-drug cocrystals/salts synthesized based on the crystal engineering design are reviewed. This may provide theoretical support for the development of the new solid-state combinational drugs.
