Five new gingerol compounds from Zingiberis Rhizoma
10.16438/j.0513-4870.2020-0538
- VernacularTitle:干姜中五个新的姜辣素类化合物
- Author:
Xiao-juan ZHANG
1
;
Yan-zhi WANG
2
;
Man-qian LI
1
;
Zhi-min SONG
1
;
Yan GUO
1
;
Xue-yu HU
1
;
Wei-sheng FENG
2
Author Information
1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
2. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; Respiratory Disease Diagnosis and Treatment and New Drug Development Henan Collaborative Innovation Center, Zhengzhou 450046, China
- Publication Type:Research Article
- Keywords:
Zingiberis Rhizoma;
gingerol;
spectrum technology;
isolation and identification
- From:
Acta Pharmaceutica Sinica
2020;55(10):2421-2427
- CountryChina
- Language:Chinese
-
Abstract:
We separated and purified five chemical constituents of dried ginger by Diaion HP-20, Sephadex LH-20, silica gel and semi-preparative high performance liquid chromatography. Five gingerols were identified by physicochemical properties and MS and NMR spectroscopy techniques: 4-(2-butyl-6-methyl-4H-pyran-4-yl)-2-methoxyphenol (1), 4-(2-hexyl-6-methyl-4H-pyran-4-yl)-2-methoxyphenol (2), 1-(4-hydroxy-3-methoxyphenyl)tridecane-3,5-diol (3), [10]-gingerdiol (4) and 1-[1-(4-hydroxy-3-methoxy phenyl)-3-oxodecan-5-yl]pyrrolidin-2-one (5a, 5b). Compounds 1-3, 5a, 5b are new compounds.
