Advances in the study of gut pharmacomicrobiomics
10.16438/j.0513-4870.2020-0455
- VernacularTitle:药物微生物组学研究进展
- Author:
Yue-mei SUN
1
;
Ya-ting ZHANG
2
;
Juan-hong ZHANG
1
;
Xue LI
2
;
Rong WANG
3
;
Wen-bin LI
1
Author Information
1. Key Laboratory for Prevention and Remediation of Plateau Environmental Damage, the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, China
2. College of Pharmacy, Lanzhou University, Lanzhou 730000, China
3. Key Laboratory for Prevention and Remediation of Plateau Environmental Damage, the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, China; College of Pharmacy, Lanzhou University, Lanzhou 730000, China
- Publication Type:Research Article
- Keywords:
intestinal flora;
pharmacokinetics;
efficacy;
plateau hypoxic environment;
individualized medication
- From:
Acta Pharmaceutica Sinica
2020;55(10):2314-2321
- CountryChina
- Language:Chinese
-
Abstract:
The intestinal flora is a diverse microbial community living in the digestive tract of humans and animals. This microbial community can modify drugs in unpredictable ways, leading to changes in the pharmacokinetics of drugs in vivo and affecting their clinical efficacy. Here we review drug metabolism mediated by intestinal flora from three aspects: prodrug activation, drug inactivation, and toxicity. The effect of the stable hypoxic environment on the composition and quantity of intestinal flora and the effect on drug metabolism are discussed. Understanding the influence of intestinal flora on drug metabolism is not only conducive to individualized medication, but also conducive to rational drug design, allowing us to predict and understand individual drug response and regulate the intestinal microbiome to improve drug efficacy, thus promoting personalized medicine.
