Advances in understanding the pathogenic factors and pathogenesis of Parkinson's disease
10.16438/j.0513-4870.2020-0344
- VernacularTitle:帕金森病致病因素及发病机制研究进展
- Author:
Sen ZHANG
1
;
Xiao-yue ZHAO
1
;
Yu LIANG
1
;
Sha LI
1
;
Guan-hua DU
1
Author Information
1. Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
Parkinson's disease;
pathogenic factor;
pathogenesis;
therapeutic drug
- From:
Acta Pharmaceutica Sinica
2020;55(10):2264-2272
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease (PD) is the second most common neurodegenerative disease of the central nervous system. It is currently believed that PD is related to factors such as age, gender, family inheritance, gene mutation and environment. The pathogenesis of PD is complex and is related to dysfunction and loss of dopaminergic neurons, involving accumulation of α-synuclein, neuroinflammation, oxidative stress, mitochondrial dysfunction and excessive accumulation of neuromelanin. In many ways, various factors act both independently and through cross-promotion, resulting in an ongoing pattern of brain tissue damage and progressing PD pathology. This article reviews the recent research on the pathogenic factors and pathogenesis of PD and explores new ideas and potential targets for PD treatment and drug development.
