Advances in the research of exosome and exosomal non-coding RNA in the pathogenesis, diagnosis and treatment of polycystic ovary syndrome
10.16438/j.0513-4870.2020-0323
- VernacularTitle:外泌体及其携带的非编码RNA在多囊卵巢综合征发病机制及诊疗中的研究进展
- Author:
Yi-kai LIAN
1
;
Wei-dong ZHOU
1
Author Information
1. Reproductive Medicine Center, the First Affiliated Hospital of Xiamen University, Xiamen 361100, China; School of Medicine, Xiamen University, Xiamen 361102, China
- Publication Type:Research Article
- Keywords:
polycystic ovary syndrome;
exosome;
non-coding RNA;
mechanism;
iagnosis and treatment
- From:
Acta Pharmaceutica Sinica
2020;55(10):2256-2263
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease, which is mainly characterized by hyperandrogenemia, rare or anovulation, and polycystic ovarian changes. PCOS is seriously harmful and its causes are complex, which has not yet been clarified. Studies have shown that non-coding RNAs play important roles in the development of PCOS, including the regulation of hormone metabolism and follicle development. Exosomes are natural nano-scale membrane vesicles that contain cell-specific proteins, lipids, nucleic acids, and other biologically active molecules. Exosomes are important mediators for intercellular communication and new targets for disease diagnosis and treatment. Recent studies have shown that as an important component of follicle microenvironment, exosome is closely related to the pathogenesis of PCOS. Exosome and exosomal non-coding RNAs are expected to serve as potential new diagnostic and therapeutic targets for PCOS. In this review, we will summarize the function of exosome and exosomal non-coding RNA in the pathogenesis, diagnosis, and treatment of PCOS.
