Function of myeloid-derived suppressor cells and strategy of reversal immunosuppression
10.3872/j.issn.1007-385x.2020.10.001
- VernacularTitle:髓源抑制性细胞的功能及其逆转策略
- Author:
QIN Guohui
1
;
ZHANG Yi
1
Author Information
1. Biotherapy Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China
- Publication Type:Journal Article
- Keywords:
myeloid-derived suppressor cells (MDSCs);
immunosuppressive function;
MDSC production and migration;
combined
- From:
Chinese Journal of Cancer Biotherapy
2020;27(10):1073-1080
- CountryChina
- Language:Chinese
-
Abstract:
Myeloid-derived suppressor cells (MDSCs) are a group of highly heterogeneous immunosuppressive cells produced in the
bone marrow, which accumulate in large amounts under pathological conditions such as malignant tumors. MDSCs are the significant
cell subsets that reduce patients' response to traditional treatment and promote tumor progression. In recent years, immune checkpoint
blockade and adoptive transfusion of engineered T cells have significantly prolonged the survival of many patients with advanced malignant tumors, but the effective rate from 15% to 40% in some solid tumors including lung cancer, colorectal cancer etc., which is closely related to the immunosuppressive microenvironment in solid cancers. With the accumulation in tumor microenvironment, MDSCs reduce the anti-tumor immune response of patients by inhibiting T cell or NK cell proliferation and function, which is the key mechanism for patients tolerating to immunotherapy. Therefore, clarifying the accumulation and functional characteristics of MDSCs is an important research direction to explore the improvement of restoring immunotherapy. This article will systematically elaborate the regulatory mechanism of MDSC production, aggregation and immunosuppressive function, and outline the latest research progress of targeted MDSC therapy
- Full text:20201001.pdf
