A Case of Hemophagocytic Syndrome Manifested as Generalized Skin Eruption in Childhood Atopic Dermatitis.
- Author:
Soo Jung PARK
1
;
Hyun Jung SONG
;
Chang Wook KIM
;
Kyu Suk LEE
Author Information
1. Department of Dermatology, Keimyung University School of Medicine, Daegu, Korea. dermaok@dsmc.or.kr
- Publication Type:Case Report
- Keywords:
Hemophagocytic macrophage;
Hemophagocytic syndrome
- MeSH:
Adolescent;
Biopsy;
Bone Marrow;
Dermatitis, Atopic*;
Drug Therapy, Combination;
Extremities;
Ferritins;
Fever;
Histiocytes;
Humans;
Hypertriglyceridemia;
Liver;
Lymphatic Diseases;
Lymphocytes;
Lymphohistiocytosis, Hemophagocytic*;
Macrophages;
Oxidoreductases;
Pancytopenia;
Panniculitis;
Physical Examination;
Pruritus;
Purpura;
Sensation;
Skin*
- From:Korean Journal of Dermatology
2006;44(4):470-473
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of 15-year-old patient, previously diagnosed with atopic dermatitis, who presented with generalized erythematous purpuric patches and petechiae on the face, trunk and extremities. The skin lesions appeared 7 days prior to presentation, accompaied by a high grade fever (38.9 degrees C). The lesions had rapidly become aggrevated after an upper respiratory infection, resulting in severe itching sensation. On physical examination, hepatosplenomegly and cervical lymphadenopathy were noted. The laboratory test showed marked pancytopenia, elevated liver enzymes, hypertriglyceridemia, elevated lactic dehydrogenase level and increased ferritin level. Many hemophagocytic macrophages were detected in bone marrow biopsy. A skin biopsy revealed panniculitis composed of histiocytes and lymphocytes. Hemophagocytic syndrome was diagnosed, and treatment with combination chemotherapy resulted in complete remission.
