Research progress on hepatotoxicity of traditional Chinese medicine based on metabonomics.
10.19540/j.cnki.cjcmm.20200322.201
- Author:
Cong HU
1
;
Hong-Wei LI
1
;
Lin-Jing WU
1
;
Yin-Hua XIONG
2
Author Information
1. School of Pharmacy, Jiangxi Science and Technology Normal University Nanchang 330013, China.
2. School of Pharmacy, Jiangxi Science and Technology Normal University Nanchang 330013, China Jiangxi Provincial Key Laboratory of Drug Design and Evaluation Nanchang 330013, China.
- Publication Type:Journal Article
- Keywords:
hepatotoxicity;
metabonomics;
traditional Chinese medicine
- MeSH:
Chemical and Drug Induced Liver Injury;
Drug-Related Side Effects and Adverse Reactions;
Drugs, Chinese Herbal;
Humans;
Medicine, Chinese Traditional;
Metabolomics
- From:
China Journal of Chinese Materia Medica
2020;45(11):2493-2501
- CountryChina
- Language:Chinese
-
Abstract:
With the continuous development of Chinese medicine, traditional Chinese medicine(TCM) has been widely used in the treatment of diseases and health care. At the same time, the toxic and side effects of TCM have been gradually concerned. The liver, as an important place for drug metabolism, is a major target organ for drug toxicity. Clinical reports on liver injury caused by TCM are common, and the problem of liver toxicity of TCM has become an important reason to limit the internationalization of TCM. Metabono-mics is a newly booming subject to study the metabolic pathway of biological system. It shows integrity and systematicness in the study of hepatotoxicity of TCM, which provides a new technical method for finding the early biomarkers of liver injury of TCM and exploring the mechanism of hepatotoxicity of TCM. In this paper, the methods of metabonomics in the study of hepatotoxicity of TCM, as well as the research progress of hepatotoxicity monomer, extract and attenuation of hepatotoxic TCM based on metabonomics were reviewed in order to provide reference for the further study of hepatotoxicity of TCM.
