Mechanism of the inhibitory effect of galangin on hepatoma cells
10.3969/j.issn.1001-5256.2020.08.040
- VernacularTitle:高良姜素对肝癌细胞抑制作用的机制
- Author:
Cheng LI
1
;
Huiwen ZHANG
1
;
Pengfei RONG
1
Author Information
1. Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha 410013, China
- Publication Type:Research Article
- Keywords:
carcinoma, hepatocellular;
galangin;
tumor suppressor proteins
- From:
Journal of Clinical Hepatology
2020;36(8):1862-1865
- CountryChina
- Language:Chinese
-
Abstract:
The mortality rate of hepatocellular carcinoma (HCC) remains high, and although there have been several treatment methods, HCC patients still have poor treatment outcome and prognosis in clinical practice. Therefore, it is necessary to find a new drug for the treatment of HCC to improve patients’ survival rate. This article introduces a new antitumor drug, galangin, which can exert an antitumor effect by inhibiting cell proliferation, promoting apoptosis, inducing autophagy, and inhibiting metastasis. In addition, galangin can also inhibit angiogenesis in liver cancer, reverse multidrug resistance, and enhance the synergistic effect between drugs. Therefore, galangin is believed to have a promising future in clinical practice, and it is expected that more studies will focus on the anti-hepatoma cell mechanism of galangin to provide a scientific basis for the clinical translation of galangin.
