Comparison of effect of total intravenous anesthesia with propofol and combined intravenous-inhala-tional anesthesia with sevoflurane on postoperative sleep quality in elderly female patients
10.3760∕cma.j.issn.0254-1416.2019.10.006
- VernacularTitle:丙泊酚全凭静脉麻醉与七氟醚静吸复合麻醉对老年女性患者术后睡眠质量影响的比较
- Author:
Fuguo MA
1
;
Yanli LIU
;
Qian WANG
;
Lixin SUN
;
Mingshan WANG
Author Information
1. 青岛市市立医院麻醉科 266000
- Keywords:
Propofol;
Anesthetics,inhalation;
Anesthesia,general;
Aged;
Femininity;
Sleep quality
- From:
Chinese Journal of Anesthesiology
2019;39(10):1168-1171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effect of total intravenous anesthesia with propofol and com-bined intravenous-inhalational anesthesia with sevoflurane on postoperative sleep quality in elderly female patients.Methods One hundred and twenty patients,aged 65-80 yr,with body mass index of 18.5-25.0 kg/m2,of American Society of Anesthesiologists physical status Ⅰ-Ⅲ,scheduled for elective gyne-cological laparoscopic operation,were divided into 2 groups(n＝60 each)by a random number table meth-od: total intravenous anesthesia with propofol group(group P)and combined intravenous-inhalational anes-thesia with sevoflurane group(group S).Anesthesia was induced with intravenous etomidate 0.2-0.3 mg/kg,sufentanil 0.2-0.4 μg/kg and cisatracurium 0.10-0.15 mg/kg.Anesthesia was maintained as fol-lows: propofol was given by target-controlled infusion with the target plasma concentration set at 2-4 μg/ml in group P,1.2-2.3％sevoflurane was inhaled in group S,and sufentanil 0.2-0.3 μg/kg and cisatracuri-um 0.04-0.06 mg/kg were intermittently injected in two groups.The patients were followed up at 7-8 a.m.on the day of hospitalization,the day of operation and 1,3,7 and 30 days after operation.The Pittsburgh Sleep Quality Index(PSQI)was recorded,PSQI> 7 points was considered as sleep disorders,and the oc-currence of sleep disorders was recorded.The morning urine was collected at the time points mentioned a-bove,and the concentrations of melatonin sulfate and free cortisol were determined by enzyme-linked immu-nosorbent assay.Results Compared with group S,the PSQI was significantly decreased on 3 and 7 days after operation,the incidence of sleep disorder was decreased on 7 days after operation,the concentrations of melatonin sulfate in urine were increased(P＜0.05),and no significant change was found in free cortisol in urine in group P(P>0.05).Conclusion The effect of total intravenous anesthesia with propofol on postoperative sleep quality is less than that of combined intravenous-inhalational anesthesia with sevoflurane in elderly female patients.
