Advance in biomarkers of neuromyelitis optica
10.3760/cma.j.issn.2095-0160.2018.12.016
- VernacularTitle:视神经脊髓炎生物标志物的研究进展
- Author:
Jun CHEN
1
Author Information
1. 广西医科大学第一附属医院眼科
- Keywords:
Neuromyelitis optica;
Aquaporin-4;
Myelin-oligodendrocyte glycoprotein;
Aquaporin-1;
Glial fibrillary acidic protein
- From:
Chinese Journal of Experimental Ophthalmology
2019;36(12):973-976
- CountryChina
- Language:Chinese
-
Abstract:
Neuromyelitis optica (NMO) is an autoimmune,demyelinating disease of the central nervous system manifesting with optic neuritis and longitudinally extensive transverse myelitis.Aquaporin-4 (AQP4)-IgG is currently regarded as a specific biomarker of NMO.Nevertheless,AQP4-IgG seronegativity in 10％-25％ of NMO patients suggests that there are several other factors involved in NMO immunopathogenesis.In this article,we reviewed current knowledge about biomarkers of NMO from AQP4,myelin-oligodendrocyte glycoprotein,AQP1 and glial fibrillary acidic protein,providing a new insight in the diagnosis of NMO.
