Research progress on ion channels and receptors in nodose ganglion neurons involved in blood pressure regulation
10.16438/j.0513-4870.2020-0877
- VernacularTitle:结状神经节神经元离子通道和受体参与血压调节的研究进展
- Author:
Li-fang HUO
1
;
Zhan-feng JIA
2
;
Wei ZHANG
1
Author Information
1. Institute of Chinese Integrative Medicine, Hebei Medical University, Shijiazhuang 050017, China
2. The Key Laboratory of New Drug Pharmacology and Toxicology, Hebei Medical University, Shijiazhuang 050017, China
- Publication Type:Research Article
- Keywords:
nodose ganglion;
ion channel;
receptor;
baroreflex;
hypertension
- From:
Acta Pharmaceutica Sinica
2020;55(7):1364-1372
- CountryChina
- Language:Chinese
-
Abstract:
Hypertension is the most common cardiovascular disease. In recent years, reduced baroreceptor activity has been suggested as a main cause of hypertension. The cell body of the primary afferent nerve of the baroreceptor is located in the nodose ganglion (NG). The ion channels and receptors in the NG can affect baroreceptor sensitivity and neuronal excitability, thus regulating blood pressure. This review focuses on recent research progress on ion channels, receptors and other proteins in NG neurons that are involved in modulating the sensitivity of the baroreceptor reflex to regulate blood pressure.
