Advances in signal regulation and detection strategies for autophagy in fungal cells
10.16438/j.0513-4870.2020-0873
- VernacularTitle:真菌细胞自噬的信号调节和检测策略研究进展
- Author:
Wan-zhen YANG
1
;
Jie TU
2
;
Na LIU
2
;
Chun-quan SHENG
3
Author Information
1. Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
2. The Second Military Medical University, Shanghai 200433, China
3. Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; The Second Military Medical University, Shanghai 200433, China
- Publication Type:Research Article
- Keywords:
autophagy;
autophagy-related gene;
fungi;
etection;
autophagy drug target
- From:
Acta Pharmaceutica Sinica
2020;55(7):1431-1438
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a widespread and unique degradation process in eukaryotic cells. When cells are under various stress conditions such as nutritional deficiencies, growth factor deficiencies or hypoxia, autophagy will be initiated to maintain the stability of the internal environment and ensure normal proliferation and differentiation. At present, research on autophagy-related targets is mostly focused on tumor cells. In contrast, research on fungal autophagy targets is still limited. Autophagy plays an important role in growth, development and morphological changes of fungal cells, suggesting that research on fungal autophagy as a drug target should be useful. This article reviews the signal regulation and detection strategies for autophagy in fungal cells, and provides a research basis for the screening of antifungal drugs targeting autophagy-related proteins.
