Recent research progress on galectin-3 as a potential therapeutic target in respiratory diseases
10.16438/j.0513-4870.2020-0581
- VernacularTitle:呼吸系统疾病潜在治疗靶点半乳糖凝集素-3的研究进展
- Author:
Rong SI
1
;
Ming-han CHENG
1
;
Jian GAO
1
Author Information
1. The Second Affiliated Hospital, School of Pharmacy, Dalian Medical University, Dalian 116023, China
- Publication Type:Research Article
- Keywords:
galectin-3;
idiopathic pulmonary fibrosis;
lung cancer;
pulmonary arterial hypertension;
bronchial asthma
- From:
Acta Pharmaceutica Sinica
2020;55(7):1401-1409
- CountryChina
- Language:Chinese
-
Abstract:
Galectin-3 is an endogenous β-galactoside-binding lectin widely distributed in the human body, and it plays an important role in various functions such as cell proliferation, differentiation, apoptosis, cell adhesion, immune response and signal transduction. Accumulating evidence has shown that galectin-3 is involved in the occurrence and development of respiratory diseases, including idiopathic pulmonary fibrosis, lung cancer, pulmonary hypertension and bronchial asthma. This review summarizes and analyzes the research progress on galectin-3 in the above respiratory diseases in order to clarify its role and mechanism, and to provide new ideas for clinical treatment.
