Research advancement in vascular endothelial cell metabolism and tumor angiogenesis
10.16438/j.0513-4870.2020-0134
- VernacularTitle:血管内皮细胞代谢与肿瘤血管新生研究进展
- Author:
Nan AN
1
;
Zi-qi CHEN
1
;
Min HUANG
1
Author Information
1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100009, China
- Publication Type:Research Article
- Keywords:
endothelial cell;
cell metabolism;
tumor angiogenesis;
tumor microenvironment;
antitumor drug
- From:
Acta Pharmaceutica Sinica
2020;55(7):1373-1381
- CountryChina
- Language:Chinese
-
Abstract:
Vascular endothelial cells play a major role in maintaining the oxygen and nutrient supply to all tissues in the body. Endothelial cells, together with vascular endothelial growth factor, are also the driving forces of tumor angiogenesis, a process describing the growth of blood vessels from the existing vasculature in tumor tissues. Reprogramming of endothelial cell metabolism satisfied the needs for biomass and energy in the process of tumor angiogenesis, which are known to involve the aspects of glucose metabolism, amino acid metabolism, and fatty acid metabolism. Recently, with the increasing interest to understand the metabolic regulation in cancer, the investigation into the metabolism of endothelial cells has made progress. We herein review the role of endothelial cell metabolism in angiogenesis, with a particular focus on the metabolic regulation of endothelial cells in tumor angiogenesis, which hopes to provide insights for the intervention of tumor angiogenesis in cancer therapy.
