Advances in mechanisms for psoriasis and drug regulation
10.16438/j.0513-4870.2019-1071
- VernacularTitle:银屑病发病机制及药物调控研究进展
- Author:
Yu-yu ZHU
1
;
Cheng-lin SONG
1
;
Yang SUN
1
Author Information
1. State Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing 210023, China
- Publication Type:Research Article
- Keywords:
psoriasis;
pathogenesis;
immune cell;
therapeutic drug;
IL-23/Th17 cell axis
- From:
Acta Pharmaceutica Sinica
2020;55(7):1393-1400
- CountryChina
- Language:Chinese
-
Abstract:
Psoriasis, bringing great trouble to patients' life, is a common chronic immune skin disease which is relapsed and difficult to cure. Further understanding of the pathogenesis of psoriasis will be benefit for potential drug targets and the development of therapeutic drugs. In recent years, "interleukin-23/T helper17 (IL-23/Th17) cell axis" has attracted more and more attention in the pathogenesis of psoriasis. Some drugs targeting the cell axis have also been successfully listed in the market to improve psoriasis and achieved good results. This review focuses on the "IL-23/Th17 cell axis" system to elaborate the role of a variety of immune cells involved in the pathogenesis of psoriasis, such as dendritic cells, macrophages, neutrophils and T cells, and summarizes multiple therapeutic antibodies targeting this cell axis in the treatment of psoriasis. In addition, this review also summarizes the current small molecule drugs for the treatment of psoriasis.
