Cohort study on the relationship between women’s pre-pregnancy age, alanine aminotransferase, blood glucose level and premature birth
10.3969/j.issn.1006-2483.2020.03.026
- VernacularTitle:妇女孕前年龄、谷丙转氨酶及血糖水平与早产关系的队列研究
- Author:
Jingyun YU
1
;
Weichao HE
1
;
Jianxin LIU
1
;
Jinguo CHEN
1
;
Bi JIANG
2
Author Information
1. Dongguan Maternal and Child Health Hospital of Guangdong Province，Dongguan，Guangdong 523000，China
2. Dongguan Maternal and Child Health Hospital of Guangdong Province，Dongguan，Guangdong 523000，China 075000, China
- Publication Type:Journal Article
- Keywords:
Alanine aminotransferase;
Blood glucose;
Premature birth;
Cohort study
- From:
Journal of Public Health and Preventive Medicine
2020;31(3):108-111
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of pre-pregnancy age, alanine aminotransferase (ALT), blood glucose (GLU) level on premature birth. Methods Based on the free pre-marital health check-ups and pre-pregnancy eugenic health check-ups in Dongguan, the examination results of the subjects were obtained and the pregnancy outcomes were followed up. Logistic regression models were used to analyze the relationship between women’s pre-pregnancy age, ALT, and GLU levels and the incidence of premature birth. Results A total of 18 150 subjects were included in this study, and the overall incidence of premature birth was 6.06% (1,099/18,150). The women’s pre-pregnancy age 30 to 34 (RR=1.26, 95% CI:1.07～1.48), age>34 (RR=1.82, 95% CI:1.52～2.18), ALT≥40 U/L (RR=1.40, 95% CI: 1.09～1.80) and GLU>6.1 mmol/L(RR=1.74, 95% CI: 1.01～2.97) were the influencing factors of premature birth. Conclusion Older women, abnormal serum alanine aminotransferase level and hyperglycemia had an impact on the occurrence of premature birth, which has important guiding significance for health education of eugenics before pregnancy.
