Advances in research on NLRP3 pyroptosis in ophthalmology
10.3980/j.issn.1672-5123.2020.8.10
- VernacularTitle:NLRP3参与的细胞焦亡在眼科疾病的研究进展
- Author:
Zhao-Wei Song
1
Author Information
1. Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
- Publication Type:Review
- Keywords:
NLRP3;
pyroptosis;
age-related macular degeneration;
cataract;
pterygium;
diabetic retinopathy;
dry eye syndrome
- From:
International Eye Science
2020;20(8):1347-1350
- CountryChina
- Language:Chinese
-
Abstract:
Nucleotide-binding oligomerization domain(NOD)-like receptor family contains Pryrin domain protein 3(NLRP3)inflammasome, which is an intracellular protein complex. Large release of ROS can activate the production of intracellular NLRP3 inflammasome. It consists of NLRP3, a cysteine protease recruitment domain(ASC),and a pro-caspase-1 precursor, can activate caspase-1 while being assembled. Then, the cytokines interleukin-1 and interleukin-18(pro-Il-1/18)are cleaved into mature forms by caspase-1 to perform their pro-inflammatory functions. pyroptosis refers to the programmed cell death of Caspase-1-dependent cells mediated by inflammasome. This article reviews the structure and function of NLRP3 inflammasome, its relationship with pyroptosis, and the research progress in ophthalmic diseases.
- Full text:202008010.pdf
