Research progress of ASIC1a in inflammatory diseases
10.16438/j.0513-4870.2019-0991
- VernacularTitle:酸离子敏感通道1a在炎症性疾病中的研究进展
- Author:
Yan-yi LIU
1
;
Xiao-ming MENG
1
;
Cheng-mu HU
1
;
Wen-yong WU
2
;
Yan HUANG
1
Author Information
1. Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei 230032, China
2. Department of General Surgery, the First Affiliated Hospital, Anhui Medical University, Hefei 230022, China
- Publication Type:Research Article
- Keywords:
acid ion-sensitive channel 1a;
istribution;
inflammatory diseases;
tissue acidification;
pH
- From:
Acta Pharmaceutica Sinica
2020;55(6):1119-1124
- CountryChina
- Language:Chinese
-
Abstract:
Acid-sensing ion channel 1a (ASIC1a) is an ammonia-chlorine-sensitive ligand-gated ion channel, and is widely distributed and expressed in the central and peripheral nervous systems. In a physiological environment, cells maintain a stable pH value around 7.0-7.5 through various transport modes of H+. During the occurrence of some pathological conditions such as allergic asthma, nephritis, arthritis, enteritis, acute lung injury, and other inflammatory diseases, the anaerobic glycolysis of tissue produces H+ accumulation of lactic acid and ATP hydrolysis, resulting in tissue acidification and body fluids. The pH value drops sharply to around 4.0-6.0, which further activates ASIC1a, causing a sharp deterioration of the inflammatory disease. In recent years, targeting ASIC1a may be a potential treatment strategy. This review briefly summarizes the role of ASIC1a in inflammatory diseases and discusses the research progress of ASIC1a in inflammatory diseases.
