The physiologic and behavioral effects of midazolam in children with dental fear
10.16571/j.cnki.1008-8199.2020.05.011
- VernacularTitle: 咪达唑仑不同给药方法对牙科畏惧症患儿镇静效果的影响
- Author:
Yue ZHAO
1
;
Qiu-fang CHANG
1
;
Yang YE
1
;
Jing GAO
1
;
Hong-yan LIANG
1
;
Chun LU
2
Author Information
1. Department of Stomatology,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology, Baotou 014010, Inner Mongolia, China
2. Tooth Fairy Dental Clinic, Jian′ye District, Nanjing 210019, Jiangsu, China
- Publication Type:Journal Article
- Keywords:
midazolam；dental fear；physiology and behavior;
oraldrugs;
nasal groups
- From:
Journal of Medical Postgraduates
2020;33(5):504-508
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveFor children with dental fear who refuse to take oral medicine, the advantage of nasal administration remains undetermined. The purpose of the study was to compare the effectiveness of oral and intranasal midazolam in children with dental fear by evaluating their physiological and behavioral responses.MethodsFrom January 2018 to May 2019, 112 children were selected from the Department of Stomatology, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of science and technology. Children were randomly divided into two groups: the oral group (oral midazolam) and the nasal group (nasal spray was used to spray midazolam into the nose), with 56 cases in each group. The sleep status, crying status, movement status and behavior scores were recorded at the beginning of administration, binding plate, local anesthesia, 5min, 10min, 15min, 20min and 25min respectively. The scores of Ramsay scale and behavior were compared between the two groups.ResultsThere was no significant difference in sleep score between oral group (2.01±0.11) and nasal group (1.98±0.24) (P>0.05). The crying score [(2.0±0.3)], movement score [(2.1±0.1)], and behavior score [(2.0±0.5)] in the nasal group were significantly higher than those in the oral group [(1.3±0.1), (1.3±0.3), (1.4±0.2)], the difference was statistically significant (P<0.05); the above scores were also significantly higher at the beginning of local anesthesia (P<0.05). There was no significant difference in Ramsay Sedation between the two groups (P>0.05). ConclusionOral midazolam and intranasal midazolam have similar sedative effects for relieving children′s anxiety. However, the sedation effect was faster of oral midazolam, which can provide guidance for children in clinical oral medicine.
