Relationship between parasitic infections and hygiene hypothesis: a review
10.16250/j.32.1374.2019115
- VernacularTitle:寄生虫感染与“卫生假说”关系研究进展
- Author:
Sha-Sha MU
1
;
Jun-Qi YANG
1
Author Information
1. Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention; Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology; Jiangsu Institute of Parasitic Diseases; Center for Public Health Research, Jiangnan University, Wuxi 214064, China
- Publication Type:Journal Article
- Keywords:
Parasitic infection;
Hygiene hypothesis;
Regulatory T cells;
Th17 cells
- From:
Chinese Journal of Schistosomiasis Control
2020;32(2):203-207
- CountryChina
- Language:Chinese
-
Abstract:
Recently, the incidence of infectious diseases continues to decline in many developed countries; however, the incidence of autoimmune diseases and allergic asthma appears a tendency towards a rise over years. “Hygiene hypothesis” provides new insights into the treatment of autoimmune disorders and allergic diseases based on parasitic infections. Increasing evidence shows that parasitic infections may effectively inhibit the development of diabetes, multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis and allergic asthma. There are complex mechanisms underlying the relationship between parasitic infections and “hygiene hypothesis”, among which regulatory T (Treg) cells and Th17 cells are becoming a hot topic of research. This paper reviews the progresses in the research on the relationship between parasitic infections and “hygiene hypothesis”, and summarizes the roles of Treg cells and Th17 cells in the interplay between parasitic infections and “hygiene hypothesis”.
