Gleason scores in prostate needle biopsy and prostatectomy specimens in prostatic adenocarcinoma: A correlation study
- Author:
Asmawiza Awang
1
Author Information
1. Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia,
- Collective Name:Nurismah Md Isa; Rosna Yunus; Shamsul Azhar Shah; Suria Hayati Md Pauzi
- Publication Type:Journal Article
- Keywords:
Prostate adenocarcinoma;
Gleason grading;
Gleason pattern 4;
Needle biopsy;
Radical prostatectomy;
Prognostic grade group
- From:The Malaysian Journal of Pathology
2019;41(3):253-257
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Gleason scoring (GS) categorised prostatic adenocarcinoma into five prognostic grade
groups (PGGs); associated with different prognosis and treatment. This study aims to correlate
between Gleason scores of needle biopsies with the corresponding total prostatectomy specimens,
and to assess the relationship between the percentage of Gleason 4 tumour pattern (GP4) within
Gleason score 7 (GS7) needle biopsy groups with the pathological staging. Materials and Methods:
Seventy-eight specimens of needle prostate biopsy and its subsequent radical prostatectomy were
retrospectively studied. The GSs of the needle biopsy were compared with the corresponding
prostatectomy specimens. The percentage of GP4 in GS7 needle biopsy groups was calculated
and correlated with the pathological staging. Results: More than half (60%) of GS 6 needle biopsy
cases (PGG 1) were upgraded in the prostatectomy specimen, while the majority (80%) of the GS7
needle biopsy groups (PGG 2 and 3) remain unchanged. Cohen’s Kappa shows fair agreement in
the Gleason scoring between needle biopsies and prostatectomy specimens, K = 0.324 (95% CI,
6.94 to 7.29), p <0.0005 and in the percentage of GP4 in GS7 needle biopsy groups and their
corresponding radical prostatectomy specimens, K = 0.399 (95% CI 34.2 – 49.2), p<0.0005. A
significant relationship was seen between the percentage of GP4 in GS7 needle biopsy with the
pT and pN stage of its radical prostatectomy (p = 0.008 and p=0.001 respectively). Conclusion: A
higher percentage of GP4 in GS7 tumour is associated with worse tumour behaviour, therefore it
is crucial for clinicians to realise this in deciding the optimal treatment.
- Full text:5.2019my01019.pdf
