New progress in medicinal chemistry of anti-poxvirus drugs research
10.16438/j.0513-4870.2019-0954
- VernacularTitle:抗痘病毒药物化学研究新进展
- Author:
Tao ZHANG
1
;
Zhong-xia ZHOU
1
;
Peng ZHAN
1
;
Xin-yong LIU
1
Author Information
1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
- Publication Type:Research Article
- Keywords:
poxvirus;
Orthopoxvirus;
inhibitor;
target;
rug design
- From:
Acta Pharmaceutica Sinica
2020;55(4):734-743
- CountryChina
- Language:Chinese
-
Abstract:
Poxvirus is the largest and most complex virus of the known virions, and the main pathogenicity to humans is Orthopoxvirus. In recent years, with the deep understanding of the biological structure and replication cycle of Orthopoxvirus, new small molecular compounds with high efficiency and low toxicity have been discovered as new drugs, and some have entered the clinical trial stage. This article summarizes the research progress of poxvirus inhibitors with different targets.
